Kinrix

Generic Name: diphtheria, tetanus, acellular pertussis, polio vaccine (Intramuscular route)

dif-THEER-ee-a TOX-oyd, ad-SORBD, TET-n-us TOX-oyd, per-TUS-iss VAX-een, a-SELL-yoo-lar, POE-lee-oh VYE-rus VAX-een, in-AK-ti-vated

Commonly used brand name(s)

In the U.S.

• Kinrix

Available Dosage Forms:

• Suspension

Therapeutic Class: Vaccine

Uses For Kinrix

Diphtheria, tetanus, and acellular pertussis vaccine (also known as DTaP) combined with inactivated poliovirus vaccine (also known as IPV) is a combination vaccine that is given to protect against infections caused by diphtheria, tetanus (lockjaw), pertussis (whooping cough), and poliovirus. The vaccine works by causing the body to produce its own protection (antibodies) against these diseases. This vaccine is given only to children who are 4 to 6 years of age, and is given before the child’s 7th birthday.

Diphtheria is a serious illness that can cause breathing difficulties, heart problems, nerve damage, pneumonia, and possibly death. The risk of serious complications is greater in very young children and the elderly.

Tetanus (also known as lockjaw) is a very serious illness that causes seizures and severe muscle spasms that can be strong enough to cause bone fractures of the spine. The disease continues to occur almost exclusively among people who do not get vaccinated or do not have enough protection from previous vaccines.

Pertussis (also known as whooping cough) is a serious disease that causes severe spells of coughing that can interfere with breathing. Pertussis can also cause pneumonia, long-lasting bronchitis, seizures, brain damage, and death.

Polio is a very serious infection that causes paralysis of the muscles, including the muscles that enable you to walk and breathe. A polio infection may leave a person unable to breathe without the help of a breathing machine. It may also leave a person unable to walk without leg braces or being confined to a wheelchair. There is no cure for polio.

This vaccine is to be administered only by or under the supervision of your child’s doctor.

Before Using Kinrix

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of this vaccine in children younger than 4 years of age and children 7 years of age and older. Safety and efficacy have not been established.

Geriatric

This vaccine is not recommended for use in adult patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:

• Disease of the brain (e.g., encephalopathy)—This includes a coma, a decreased level of consciousness, or seizures lasting a long time. Children who have these symptoms within seven days of receiving a vaccine with pertussis should not get this vaccine.

• Fever, high or


• Moderate or severe illness, with or without fever—This vaccine may make these conditions worse or may increase the chance of side effects.

• Guillain-Barre syndrome (nerve disease that causes paralysis), history of—If your child had this condition after getting a vaccine with tetanus in it, you should talk to your doctor about the potential benefits and possible risks of getting this vaccine.

• Immunodeficiency disorder or


• Weakened immune system—This vaccine may not work as well in children with these conditions.

• Previous serious reaction to a vaccine—If your child has had a serious reaction to this vaccine or another vaccine with pertussis in it, you should talk to your doctor about the potential benefits and possible risks of getting this vaccine. Some serious reactions include being less responsive than normal, crying continuously without stopping for 3 hours or more, having a seizure with or without fever, or having a fever that was 105 degrees F or higher.

• Progressive neurologic disorder—This includes infantile spasms, progressive brain disease, or uncontrolled seizures. This vaccine should not be given until these conditions are treated and under control.

Proper Use of Kinrix

A nurse or other trained health professional will give your child this vaccine. This vaccine is given as a shot into one of your child’s muscles, usually in the shoulder muscle.

Your child may receive other vaccines at the same time as this one, but in a different body area. You should receive information sheets about all of the vaccines your child receives. Make sure you understand all of the information that is given to you.

Your child may also receive a medicine to help prevent or treat some of the minor side effects of the vaccine, such as fever and soreness.

Precautions While Using Kinrix

It is very important that the doctor check your child at regular visits to make sure this vaccine is working properly and to check for unwanted effects.

Tell your child’s doctor about all other vaccines your child has had, especially if those vaccines were part of a series. This vaccine might be used to finish a series of vaccines.

Make sure your doctor knows if your child is allergic to latex rubber. One of the prefilled syringes for this vaccine contains dry natural latex rubber. This may cause an allergic reaction in children who are sensitive to latex. .

This vaccine will not treat an active infection. If your child has an infection due to diphtheria, tetanus, pertussis, or polio, your child will need medicines to treat these infections.

Be sure to tell your child’s doctor about any serious side effects that occur after your child receives the vaccine. This may include fainting, seizures, a high fever, crying that will not stop, or severe redness or swelling where the shot was given.

Kinrix Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Abdominal or stomach pain


• blurred vision


• confusion


• decreased urination


• diarrhea


• difficulty having a bowel movement (stool)


• dizziness


• dry mouth


• fainting


• fast heartbeat


• fever


• high blood pressure


• inability to speak


• increase in heart rate


• irritability


• itching, pain, redness, swelling, tenderness, or warmth on the skin


• lightheadedness


• loss of appetite


• muscle twitching


• nausea


• rapid breathing


• restlessness


• seizures


• severe or sudden headache


• slurred speech


• sunken eyes


• swelling of the feet or lower legs


• temporary blindness


• thirst


• unusual tiredness or weakness


• weakness


• weakness in the arm and/or leg on one side of the body, sudden and severe


• wrinkled skin

Incidence not known

• Black, tarry stools


• bleeding gums


• blood in the urine or stools


• bluish lips or skin


• collapse or shock-like state


• cough


• difficulty swallowing


• hives


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• pinpoint red spots on the skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• shortness of breath


• skin rash


• slow breathing


• swollen, painful, or tender lymph glands in neck, armpit, or groin


• tightness in the chest


• unusual bleeding or bruising


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Loss of appetite


• pain, redness, or swelling at the injection site


• sleepiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Kinrix side effects (in more detail)

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More Kinrix resources

• Kinrix Side Effects (in more detail)
• Kinrix Use in Pregnancy & Breastfeeding
• Kinrix Drug Interactions
• Kinrix Support Group
• 0 Reviews for Kinrix - Add your own review/rating

• Kinrix Prescribing Information (FDA)


• Kinrix MedFacts Consumer Leaflet (Wolters Kluwer)


• Kinrix Consumer Overview

Compare Kinrix with other medications

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• Pertussis Prophylaxis
• Poliomyelitis Prophylaxis
• Tetanus Prophylaxis